PhD program
Pharmaceutical Manufacturing Technology

Pharmaceutical Manufacturing Technology

QUALIFICATION

  • Scientific and pedagogical direction - Doctor of Philosophy (PhD)

MODEL OF GRADUATING STUDENT

1. Possesses knowledge and modern innovative technologies for solving tasks in the field of organization, creation, production, and standardization of original medicines based on natural and synthetic raw materials, taking into account economic and environmental factors, their pharmacokinetics, and bioequivalence.
2. Is capable of directed design of new pharmaceutical drugs based on computer and mathematical modeling, macromolecular polymer design, development of nanopharmaceuticals; comprehensive and complete identification of active pharmaceutical ingredients and drugs based on highly effective physicochemical methods.
3. Demonstrates the ability to organize, plan, and manage the activities of pharmaceutical organizations and enterprises in accordance with the current legislation of the Republic of Kazakhstan in the field of healthcare, Good Pharmaceutical Practices GxP (GMP, GLP, GSP, GDP, GPP), and principles of modern marketing and management.
4. Organizes work to ensure and control the quality, safety, and efficacy of medicines, addressing identified violations of pharmaceutical activities in the production, storage, transportation, acceptance, and sale of medicines and medical devices in accordance with the current legislation of the Republic of Kazakhstan in the field of healthcare and Good Pharmaceutical Practices (GxP).
5. Organizes systems of external and internal audits of entities engaged in pharmaceutical activities, demonstrating knowledge of Good Pharmaceutical Practices (GxP) and the current legislation of the Republic of Kazakhstan.
6. Analyzes and controls documentation related to the handling of medicines at all stages of their lifecycle: standard operating procedures, instructions, contracts, records, reports, test protocols, and other data.
7. Organizes a system for monitoring, analyzing, and evaluating information on the safety of medicines in accordance with the current legislation of the Republic of Kazakhstan in the field of healthcare and Good Pharmacovigilance Practices (GVP), using various methods to assess the efficacy and safety of medicines during monitoring of their adverse effects, organizing the collection and analysis of information on the safety of medicines.
8. Applies modern information and computer technologies in the collection, storage, processing, analysis, and transmission of professional information in the process of scientific and pedagogical activities at the university, as well as in production-technological, design-engineering, scientific-research, and organizational-management activities.

Program passport

Speciality Name
Pharmaceutical Manufacturing Technology
Speciality Code
8D07201
Faculty
Chemistry and Chemical Technology

disciplines

Academic writing
  • Number of credits - 2
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline is to form the ability of doctoral students to express their approaches and conclusions based on the results of scientific research, arguments and hypotheses as a style of academic writing. The training course forms the methodological basis for presenting research results in the open press, periodicals, international conferences and communication with scientists from other countries, as well as in the form of applications for participation in the competition. As a result of acquisition the course, the doctoral student will be able to: - write scientific articles for publication in international scientific journals indexed in the Scopus and Web of Science databases; -critically analyze scientific works, by indicating their advantages and disadvantages; -prepare a dissertation thesis, clearly presenting the purpose and objectives of the research, discussing the results and formulating conclusions based on the analysis of literature in a given section of chemical science; -present the content of scientific work: dissertation, monograph, review in a concise form, preserving its essence and structure; -write, present and defend scientific projects on actual problems of chemical technology of organic substances and materials.

Good practices in the production and sale of medicines
  • Number of credits - 5
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to develop the ability to deeply understand the concept of pharmaceutical sciences and technologies in the field of pharmaceutical development and pharmaceutical production of medicines. The course provides a theoretical and methodological basis for understanding the basic principles and regulatory requirements of Good Manufacturing Practices (GxP) to ensure their safety, effectiveness, proper storage and distribution.

Pharmacokinetics and bioequivalence studies: good clinical and laboratory practices
  • Number of credits - 5
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form a holistic understanding of pharmacokinetic studies of drugs in accordance with the requirements of Good Practices (GxP), all stages of bioequivalence studies, validation of methods for the quantitative determination of test substances in a biological matrix. The course forms the scientific and methodological basis of the concept of bioequivalence and methods of its implementation.

Scientific Research methods
  • Number of credits - 3
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of discipline is to give doctoral students the creative ability to consciously choose and use modern, innovative theoretical and experimental research methods for fundamental and applied research at a high level and generate results that meet international requirements. The course is a scientific and methodological base, the development of which will allow doctoral students to conduct research at a high international level, encourages them to actively participate in scientific and innovative activities and commercialization of scientific results. As a result of acquisition the course, the doctoral student will be able to: - individually set and solve scientific tasks for performing high-level research in the field of chemistry and technology of natural and synthetic organic substances and materials; - analyze scientific publications and results, determine their scientific level, and identify opportunities for their taking into account and use in their own research; - develop and implement experimental methods that allow obtaining the most reliable scientific results in the field of chemistry and technology of natural and synthetic organic substances and materials; - interpret and generalize data obtained by modern physical and physico-chemical methods; - identify, justify and interpret priority areas of development in the field of chemistry and chemical technology; plan research in these areas in the form of projects and applications for grant funding from various international and national funds; - interpret, summarize and present the results of their own research in the form of scientific articles for publication in highly rated international publications, reports at highly significant international conferences.

Data for 2021-2024 years

disciplines

Computer and mathematical modeling of medicines
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to develop the ability to use computer and mathematical modeling to develop new drugs and dosage forms, conduct their preclinical and clinical trials. The course forms the theoretical and methodological basis for the creation of new drugs, establishing their dosage regimen, optimal routes of administration, duration of treatment, their correction in case of ineffective treatment or poor tolerance by patients.

Current trends in the development of chemistry and technology for the production of herbal medicines
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to develop the ability to establish the chemical composition of plants and develop innovative technologies for the production of unique medicinal substances and preparations based on them. The discipline develops knowledge about the structure, chemical and biological properties of the active ingredients of substances, the selection of the most rational, economically and environmentally sound technologies for the production of herbal medicines, ensuring their biological safety and high efficiency.

Development of new and innovative polymer-based drug and biomaterial delivery systems
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose: to develop the ability to develop and analyze new and innovative delivery systems for drugs and biomaterials based on polymers, assessing their effectiveness, biocompatibility and functional properties. The course forms a theoretical and methodological basis for the design of polymer delivery systems, evaluation of properties and application in medicine and pharmaceuticals.

Highly effective physicochemical methods for identifying plant substances and preparations
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to develop the ability to identify the fine structure of the active substances of herbal medicinal substances and herbal remedies in various dosage forms using modern spectral and chromatographic methods. The discipline forms the theoretical and methodological basis for the methodology of research and identification of various drugs using UV, mass, 1H-NMR, 31C-NMR spectra, thin-layer, gas, gas-liquid and high-performance liquid chromatography methods.

Macromolecular design and functioning of biomedical polymers
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose: to develop the ability to apply the principles of macromolecular design to obtain multifunctional polymer materials for medical and biological purposes with the required set of properties. The discipline focuses on studying new and modern methods and technologies, the principles of polymer design, including the selection of monomers and synthesis methods used to create and analyze polymer materials with the desired properties.

Marketing and management in pharmaceutical production
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose: to develop the ability to create marketing strategies and plans, manage brands, and evaluate the effectiveness of marketing campaigns. The course is aimed at studying the fundamentals of marketing activities and management in the context of the pharmaceutical industry, the basic principles and methods of marketing research, strategies for promoting pharmaceutical products, market analysis, and the management of production and business processes in pharmaceutical companies.

Metabolic reactions and creation of prodrugs
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to develop the ability to explain the action of drugs based on metabolic reactions, to evaluate the products of transformation in the body to create prodrugs. The course forms a theoretical and methodological basis for the classification of reactions and metabolic conditions of pharmacophores of organic compounds, assessment of their stability in the body for the creation of prodrugs and principles for the development of new dosage forms.

Modern aspects of the development of nanomedicines
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose: to develop the ability to present a holistic system of theoretical foundations for development of nanomedicines, to apply the principles of pharmaceutical chemistry in the creation and assessment of the quality of nanomedicinal substances. The discipline examines modern achievements of fundamental chemical sciences and nanobiomedical technologies, sources and methods of obtaining biotechnological nanomedicinal substances, their physical and chemical properties, and the relationship of chemical structure with pharmacological properties.

Synthesis planning and creation of potentially biologically active compounds
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to develop the ability to plan targeted synthesis of biologically active compounds, to evaluate options for constructing a given structure to optimize the method for obtaining a given substance. The course forms a theoretical and methodological basis for reasoned drawing up schemes for synthesizing the structure of a given biologically active substance based on methods of targeted design of new drugs (drug design), molecular modeling and virtual screening of biological activity.

Data for 2021-2024 years

INTERNSHIPS

Pedagogical
  • Type of control - Защита практики
  • Description - Formation of practical, educational-methodical skills of conducting lectures, seminars, creatively apply scientific, theoretical knowledge, practical skills in teaching activities, conduct training sessions in the disciplines of the specialty; own modern professional techniques, methods of training, use in practice the latest theoretical, methodological advances, make educational, methodological documentation.

Research
  • Type of control - Защита практики
  • Description - The purpose of the practice: gaining experience in the study of an actual scientific problem, expand the professional knowledge gained in the learning process, and developing practical skills for conducting independent scientific work. The practice is aimed at developing the skills of research, analysis and application of economic knowledge.

Data for 2021-2024 years