Master degree program
Reproductive genetics

Reproductive genetics

QUALIFICATION

  • Scientific and pedagogical direction - Master of Natural Sciences

MODEL OF GRADUATING STUDENT

LO1. Analyze the genetic patterns of human embryonic development at the molecular, cellular, organismal levels;
LO2. Interpret the causes and mechanisms of molecular genetic and epigenetic variability;
LO3. Use molecular genetic methods to diagnose developmental disorders of the embryo and fetus;
LO4. Determine genetic factors of female and male infertility using molecular genetic methods;
LO5. Apply methods of assisted reproductive technologies (preimplantation genetic testing, intracytoplasmic sperm injection, in vitro fertilization, etc.) to solve the problem of infertility;
LO6. Develop practical recommendations based on representative and original analysis results;
LO7. Analyze scientific, technical and patent information on the topic of research using information technology;
LO8. Develop and introduce theoretical and applied disciplines into the educational process based on a student-centered approach using digital technologies, interactive methods, forms and means of teaching;
LO9. Design and carry out complex research, including interdisciplinary research, based on the analysis of fundamental and applied problems in the field of reproductive genetics;
LO10. Plan professional activities taking into account ethical and legal norms and principles of bioethics;
LO11. Develop a research plan and present the results of independent research to the scientific community;
LO12. Increase professional and personal self-education and be able to work in a team.

Program passport

Speciality Name
Reproductive genetics
Speciality Code
7M05119
Faculty
Biology and Biotechnology

disciplines

Assisted reproductive technologies
  • Number of credits - 5
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about assisted reproductive technologies (ART) used in human infertility. The following aspects will be considered: intrauterine insemination with sperm, intracytoplasmic sperm injection (ICSI), in vitro fertilisation (IVF), assisted hatching, cryopreservation of eggs, sperm and embryos, preimplantation genetic diagnosis, etc.; indications and contraindications for ART, main risks of ART.

Cell and Genetic engineering
  • Number of credits - 6
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze the achievements of cellular and genetic engineering for editing the genome of the embryo. The following aspects will be considered: ways to create diagnostic products for detection of genetic abnormalities of the embryo, the using of CRISPR / Cas9 technology for the treatment of hereditary diseases and infertility; methods of culturing embryos, stem cells.

Foreign Language (professional)
  • Number of credits - 6
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline is to form practical skills in various types of speech activity in a foreign language. The training course builds the ability to perceive, understand and translate information in the modern global space, participate in scientific events to test their own research. The discipline is aimed at improving competencies in accordance with international standards of foreign language education.

Genetics of Infertility
  • Number of credits - 5
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about genetic factors and mechanisms of female and male infertility development. The following aspects will be considered: female and male infertility clinic; genetic causes of female infertility; genetic causes of male infertility; molecular genetic methods for diagnosing infertility; mutations in the CFTR, AZF, AR, and SRY genes; numerical and structural chromosomal abnormalities in infertility.

Genetics of infertility and assisted reproductive technologies
  • Number of credits - 9
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze the genetic causes of the formation of female and male infertility. The following aspects will be considered: molecular-genetic methods for diagnosing infertility; mutations in the CFTR, AZF, AR, SRY genes; numerical and structural chromosomal abnormalities in infertility; assisted reproductive technologies (intrauterine insemination, ICSI, IVF, assisted hatching, cryopreservation, etc.).

Genomics and Molecular Diagnostics
  • Number of credits - 6
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze the content, organization, implementation of genomic information and apply methods of molecular diagnostics of genetic diseases. The following aspects will be considered: structure, organization, levels of functioning, stability and polymorphism of genomes in professional activities; methods of molecular diagnostics (DNA extraction, PCR analysis, DNA electrophoresis); analysis the results obtained using bioinformatic technologies.

History and Philosophy of Science
  • Number of credits - 3
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline is to form a holistic systemic understanding of philosophy as a special form of cognition of the world, its main sections, problems and methods of their study in the context of future professional activity. The training course forms the theoretical and methodological basis of research work.

Information Technologies in Genetics
  • Number of credits - 5
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to develop the ability to use computer programs to statistically analyse clinical and laboratory data databases. The following aspects will be considered: methodological techniques of statistics in genetics and biomedicine; statistical data analysis using software (Statistica, SPSS, STATA) and programming languages (R, Python); the use of artificial intelligence to interpret data.

Organization and planning of scientific research
  • Number of credits - 6
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline is to formulate the topic, goals and objectives of scientific research; methodology of theoretical and experimental research; analysis of theoretical and experimental research and formulation of conclusions and proposals. Undergraduates will master innovative activities, techniques for implementing and evaluating the effectiveness of scientific research, as well as the rules for registration and protection of research results.

Organization and Planning of Scientific Research (in English)
  • Number of credits - 5
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline to form the ability to apply practical skills in the organization and planning of scientific research. The discipline studies: forms and methods of planning, organization and design of scientific articles and dissertations; forms of summarizing the results of scientific research in presentations, speeches, projects, articles.

Pedagogy of Higher Education
  • Number of credits - 5
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline is to form the ability to teach in universities and colleges based on knowledge of higher school didactics, theory of education and management of education, analysis and self-assessment of teaching activities. The training course is aimed at studying the trends in the development of education and the Bologna process. The course will help you master teaching and curatorial skills, various strategies and methods of teaching and education.

Psychology of management
  • Number of credits - 3
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline is to provide scientific training of highly qualified specialists based on the study of fundamental concepts of management psychology, creating prerequisites for a theoretical understanding and practical application of the most important aspects of the field of management in the process of professional formation. The course is aimed at studying the patterns of development and functioning of mental processes, the basics of effective interaction and conflict resolution, self-development and self-presentation.

Data for 2021-2024 years

disciplines

Clinical genetics and bioethics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze the patterns of manifestation of hereditary pathologies and genetic causes of infertility. The following aspects will be considered: the molecular, biochemical, cytological bases of genetic diseases; making a pedigree to determine the type of inheritance of the disease; the contribution of the hereditary factor to the population frequency of manifestation of pathology; methods of prevention, diagnosis and treatment of hereditary diseases; principles of bioethics in clinical genetics.

Human Embryogenesis and Developmental Genetics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about the development and formation of the embryo and the genetic patterns of individual development. The following aspects will be considered: stages of embryo development, cell differentiation processes, genetic approaches and methods for studying embryogenetic and ontogenetic mechanisms of development, and general patterns of genetic regulation of individual development.

Human genome and proteomics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze the data obtained as a result of sequencing of the human genome for specific research tasks. The following aspects will be considered: master the methods of obtaining biological information (sequencing, micro-chips, mass spectrometry), use biological information databases (GenBank, UniProt, Ensembl, etc.); use methods of analysis of genomic, metagenomic, transcriptomic, proteomic data; computer visualization tools for the analysis of nucleotide sequences.

Human Reproductive Health
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about human reproductive health. The following aspects will be considered: WHO reproductive health strategy; reproductive health of youth and adolescents; family planning and reproductive health; sexually transmitted infections; reproductive health prevention; safe abortion; human rights to reproductive health; the role of the family and the state in preserving the reproductive health of the population.

Immunogenetics and Human Reproduction
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about the molecular genetic basis of immunity. The following aspects will be considered: cellular and humoral immunity; immunoglobulins, genetics of antigens; molecular genetic methods for determining hereditary immunity factors; inheritance of the ABO blood group system; Rh factor (Rh) human major histocompatibility complex (MHC); the HLA system in infertile couples; immunogenetics of pregnancy and toxicosis.

Immunogenetics and pharmacogenetics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze the molecular-genetic basis of immunity and the individual variability of the effects of drugs. The following aspects will be considered: molecular-genetic methods to determine the hereditary factors of immunity, depending on the individual response of the body to drugs; the possibility of individualizing the choice of drugs and their dosing regimens based on the study of the genotype of a particular patient.

Information technologies in genetics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to use computer programs for the statistical analysis of the database of clinical and laboratory data. The following aspects will be considered: methodological techniques of statistics in genetics and biomedicine; statistical data analysis using software (Statistica, SPSS, STATA) and programming languages (R, Python); determination the statistical significance of differences in the compared data and interpretation the results.

Molecular cytogenetics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze chromosomal abnormalities using molecular cytogenetic methods of research. The following aspects will be considered: the structural and functional features of human chromosomes; the mechanisms of interaction of the molecular components of the chromosome; the mechanisms of formation of systemic mutations as a result of chromosome reorganization; molecular cytogenetic methods (FISH, SKY, PCR and microarray analysis of chromosomes) for the diagnosis of hereditary diseases and infertility.

Mutagenesis and epigenetics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze the patterns of mutagenesis and epigenetic inheritance. The following aspects will be considered: the theoretical and experimental foundations of the mutation process; the cause of hereditary pathologies; patterns of epigenetic inheritance and epigenetic mechanisms of embryonic stem cell differentiation; the mechanisms and ways of realization of epigenetic signals in the cell; epigenetic aspects of infertility.

Pharmacogenetics and human reproduction
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about the molecular genetic foundations of pharmacogenetics. The following aspects will be considered: pharmacokinetics and pharmacodynamics of drugs in the treatment of infertility; polymorphism of genes for enzymes that metabolise drugs; polymorphism of drug transporter protein genes; polymorphism of genes for proteins or enzymes of pharmacological targets of drugs; practical significance of pharmacogenetic testing in clinical practice.

Psychosomatics of Infertility
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about the influence of psychological factors on the course and outcome of human reproductive function. The following aspects will be considered: the biosocial nature of man; psychosomatic unity; theories of the origin of psychosomatic disorders; heredity and premorbid personality traits; psychosomatic problem of infertility in women and men; psychosomatic mechanisms of idiopathic infertility; pathogenesis of the disease; prevention, diagnosis and treatment of psychological infertility.

Reproductive biology and developmental genetics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze the mechanisms of reproduction and the genetic patterns of the development of the organism. The following aspects will be considered: the formation and development of the human reproductive system, the mechanisms of fertilization and gametogenesis; the genetic mechanisms of embryo development; genetic approaches and methods for studying embryogenetic and ontogenetic mechanisms of development; the general patterns of genetic regulation of individual development.

Reproductive Biology and Embryogenetics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about the development and manifestation of human reproductive functions in ontogenesis and the genetic patterns of embryonic development. The following aspects will be considered: the formation and development of the human reproductive system, the mechanisms of fertilisation and gametogenesis; genetic mechanisms of embryo development, and genetic approaches and methods for studying embryogenetic and ontogenetic mechanisms of development.

Reproductive Endocrinology
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about the basics of reproductive endocrinology. The following aspects will be considered: the influence of sex hormones on the formation of the reproductive system according to the female or male type; causes and genetic mechanisms of disorders of sexual development; endocrine diseases of the reproductive system of men and women; endocrine infertility; hormonal testing; the role of genetics in reproductive endocrinology.

Reproductive endocrinology and psychology
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The purpose of the discipline: to form the ability to analyze the influence of sex hormones and psychological aspects in the implementation of the reproductive function, including problems of reproductive health. The following aspects will be considered: the causes and mechanisms of typical disorders of sexual development and diseases of the genital organs; the possible psychological causes of reproductive health disorders; interpretation the results of hormonal testing in the diagnosis of endocrine reproductive disorders.

Reproductive Psychology
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to systematise knowledge about the fundamentals of human reproductive psychology. The following aspects will be considered: perinatal psychology, psychology of motherhood, psychophysiological mechanisms of the reproductive sphere, psychosomatic features of the reproductive sphere, basic principles of reproductive psychology, psychological factors of reproductive health disorders; tasks of psychological work with problems of the reproductive sphere; perinatal and reproductive psychotherapy.

Signaling Mechanisms of Human Reproduction
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to develop the ability to analyse signal interactions in implementing human reproductive function. The following aspects will be considered: primary messengers (hormones, cytokines, neurotransmitters, growth factors); receptor proteins and their ligands; secondary messengers (calcium, nitric oxide, etc.); methods and mechanisms of signal transduction; models and projects for commercialisation of signalomics; signalling systems for regulating human reproductive function.

Teratogenesis and epigenetics
  • Type of control - [RK1+MT+RK2+Exam] (100)
  • Description - The discipline aims to form the ability to analyse the patterns of teratogenesis and epigenetic inheritance. The following aspects will be considered: the theoretical and experimental foundations of the mutation process; the cause of hereditary pathologies; patterns of epigenetic inheritance and epigenetic mechanisms of embryonic stem cell differentiation; the mechanisms and ways of realisation of epigenetic signals in the cell; epigenetic aspects of infertility.

Data for 2021-2024 years

INTERNSHIPS

Pedagogical
  • Type of control - Защита практики
  • Description - Formation of practical, educational-methodical skills of conducting lectures, seminars, creatively apply scientific, theoretical knowledge, practical skills in teaching activities, conduct training sessions in the disciplines of the specialty; own modern professional techniques, methods of training, use in practice the latest theoretical, methodological advances, make educational, methodological documentation.

Research
  • Type of control - Защита практики
  • Description - The purpose of the research practice is acquaintance with the latest theoretical, methodological and technological achievements of domestic and foreign science, with modern methods of scientific research, processing and interpretation of experimental data. During the study of course, students should be competent in: - to understand the fundamental and applied research; - to understand the level of research, the stage of scientifically-research work - planning, organization and realization; - preparation, writing, representation and review of the project; - program research, methodological and procedural sections research; - systematize the base of scientific and technical information.

Data for 2021-2024 years